Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …

Although cancer stem cells have been well characterized in numerous malignancies, the
fundamental characteristics of this group of cells, however, have been challenged by some …

Background Approximately fifty percent of patients with acute myeloid leukemia can be
cured with current therapeutic strategies which include, standard dose chemotherapy for …

Acute myeloid leukaemia (AML) is a heterogeneous disease with one of the worst survival
rates of all cancers. The bone marrow microenvironment is increasingly being recognised as …

Therapies that efficiently induce apoptosis are likely to be required for durable clinical
responses in patients with solid tumors. Using a pharmacological screening approach, we …

Natural killer (NK) cells play a crucial role in recognizing and killing emerging tumor cells.
However, tumor cells develop mechanisms to inactivate NK cells or hide from them. Here …

Osteosarcoma is amongst the most prevalent bone sarcomas and majorly afflicts children
and adolescents. Therapeutic regimens based on the triad of doxorubicin, cisplatin and …

Acute myeloid leukaemia (AML) is an aggressive cancer with 50–75% of patients relapsing
even after successful chemotherapy. The role of the bone marrow microenvironment (BMM) …

Abstract Purpose of Review Apoptosis results from the interaction between pro-and anti-
apoptotic proteins, mediated by BCL-2 homology 3 (BH3) proteins. B cell lymphoma-2 (BCL …

Head and neck squamous cell carcinomas (HNSCC) are common human malignancies with
poor clinical outcomes. The 5-year survival rates for patients with advanced stage HNSCC …