Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

Presynaptic plasticity is an activity-dependent change in the neurotransmitter release and
plays a key role in dynamic modulation of synaptic strength. Particularly, presynaptic …

During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the
availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to …

Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain
reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar …

Pre-and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic
mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases …

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a
stable level that reflects the speed of replenishment of the readily releasable pool (RRP) …

The Ca 2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are
fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite …

A high rate of synaptic vesicle (SV) release is required at cerebellar mossy fiber terminals for
rapid information processing. As the number of release sites is limited, fast SV reloading is …

Synaptic heterogeneity is widely observed but its underpinnings remain elusive. We
addressed this issue using mature calyx of Held synapses whose numbers of bouton-like …

Synchronous neurotransmitter release is triggered by Ca2+ binding to the synaptic vesicle
protein Synaptotagmin 1, while asynchronous fusion and short-term facilitation is …