The treatment of renal cell carcinoma (RCC) has changed greatly over the past 15 years.
Progress in the surgical management of the primary tumor and increased understanding of …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

The discovery of a gene network regulating lysosomal biogenesis and its transcriptional
regulator transcription factor EB (TFEB) revealed that cells monitor lysosomal function and …

Kidney cancer is not a single disease but comprises a number of different types of cancer
that occur in the kidney, each caused by a different gene with a different histology and …

Summary Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant condition
characterised clinically by skin fibrofolliculomas, pulmonary cysts, spontaneous …

Abstract Birt–Hogg–Dubé (BHD) syndrome is an inherited renal cancer syndrome in which
affected individuals are at risk of developing benign cutaneous fibrofolliculomas, bilateral …

Background: Birt–Hogg–Dubé syndrome (BHDS)(MIM 135150) is an autosomal dominant
predisposition to the development of follicular hamartomas (fibrofolliculomas), lung cysts …

Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the
hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD …

Context Hereditary cases account for about 5% of all cases of renal cell carcinoma (RCC).
With advances in next-generation sequencing, several new hereditary syndromes have …

Kidney cancer represents about 5% of all new cancer diagnoses. The most common form of
kidney cancer arises from renal epithelium, named renal cell carcinoma (RCC). This entity …