▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an
exciting and active area of study. The involvement of NF-κB in the expression of numerous …

Abstract The NF-κB/REL family of transcription factors pivotally control the inflammatory and
immune responses, as well as other genetic programmes that are central to cell growth and …

The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …

A number of pathogenic and proinflammatory stimuli, and the transforming growth factor-β
(TGF-β) exert opposing activities in cellular and immune responses. Here we show that the …

Rel/NF-κB proteins constitute a family of structurally-related transcription factors that are
regulated by interaction with a family of regulatory proteins, the IκB proteins. In this review …

Vertebrates respond to infection through a combination of adaptive or acquired immunity
and innate or natural immunity. The principal feature of acquired immunity is the generation …

NF-κB is a pleiotropic transcription factor with key functions in the intestinal immune system.
NF-κB family members control transcriptional activity of various promoters of …

Abstract MHC class II (MHC-II)-restricted CD4+ T cells are essential for control of
Mycobacterium tuberculosis infection. This report describes the identification and purification …

ABSTRACT NF-κB2 (p100/p52), a member of the NF-κB/Rel family of transcription factors, is
involved in the regulation of a variety of genes important for immune function. Previously, we …

The success of immunotherapy relies on the participation of all arms of the immune system
and the role of CD4+ T lymphocytes in preventing tumor growth is now well established …