Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

An insight into the critical role of gut microbiota in triggering the phthalate-induced toxicity and its mitigation using probiotics

SP Goyal, C Saravanan - Science of The Total Environment, 2023 - Elsevier
Exposure to phthalates, a major food safety concern, has been implicated in various chronic
human disorders. As dietary exposure serves as a primary exposure route for phthalate …

[HTML][HTML] Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic …

A Schaffert, I Karkossa, E Ueberham… - Environment …, 2022 - Elsevier
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as
phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the …

Adipogenic activity of chemicals used in plastic consumer products

J Völker, F Ashcroft, Å Vedøy… - … science & technology, 2022 - ACS Publications
Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in
cell and animal models. However, these well-known metabolism-disrupting chemicals …

[HTML][HTML] Critical overview on endocrine disruptors in diabetes mellitus

C Hinault, P Caroli-Bosc, F Bost… - International journal of …, 2023 - mdpi.com
Diabetes mellitus is a major public health problem in all countries due to its high human and
economic burden. Major metabolic alterations are associated with the chronic …

Prenatal low-dose DEHP exposure induces metabolic adaptation and obesity: Role of hepatic thiamine metabolism

Y Fan, Y Qin, M Chen, X Li, R Wang, Z Huang… - Journal of hazardous …, 2020 - Elsevier
Abstract Di-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitous environmental pollutant and is
widely used in industrial plastics. However, the long-term health implications of prenatal …

Exposure to endocrine-disrupting compounds such as phthalates and bisphenol A is associated with an increased risk for obesity

R Biemann, M Blüher, B Isermann - Best Practice & Research Clinical …, 2021 - Elsevier
Increasing evidence from epidemiological, animal and in vitro studies suggests that the
increased production of synthetic chemicals that interfere with the proper functioning of the …

[HTML][HTML] Structural basis of the activation of PPARγ by the plasticizer metabolites MEHP and MINCH

A Useini, F Engelberger, G Künze, N Sträter - Environment International, 2023 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) and its substitute 1, 2-cyclohexane dicarboxylic
acid diisononyl ester (DINCH) are widely used as plasticizers but may have adverse health …

Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice

X Fu, H Han, Y Li, B Xu, W Dai, Y Zhang… - Environmental …, 2021 - Wiley Online Library
Abstract Di‐(2‐ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers,
and it is widely applied in various plastic products. DEHP is an endocrine‐disrupting …

[HTML][HTML] The role of endocrine disruptors bisphenols and phthalates in obesity: current evidence, perspectives and controversies

M Dalamaga, D Kounatidis, D Tsilingiris… - International Journal of …, 2024 - mdpi.com
Excess body weight constitutes one of the major health challenges for societies and
healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of …