Mouse models for immuno-oncology
M Bosenberg, ET Liu, IY Chun, K Palucka - Trends in Cancer, 2023 - cell.com
Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our
knowledge of in vivo mechanisms underlying treatment response as well as treatment …
knowledge of in vivo mechanisms underlying treatment response as well as treatment …
Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation
L Amable, LA Ferreira Martins, R Pierre… - Nature …, 2023 - nature.com
Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production
profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c …
profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c …
Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population
GR Keele - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …
[HTML][HTML] Regulation of protein abundance in genetically diverse mouse populations
Genetically diverse mouse populations are powerful tools for characterizing the regulation of
the proteome and its relationship to whole-organism phenotypes. We used mass …
the proteome and its relationship to whole-organism phenotypes. We used mass …
Using the collaborative cross and diversity outbred mice in immunology
J Hackett, H Gibson, J Frelinger… - Current protocols, 2022 - Wiley Online Library
Abstract The Collaborative Cross (CC) and the Diversity Outbred (DO) stock mouse panels
are the most powerful murine genetics tools available to the genetics community. Together …
are the most powerful murine genetics tools available to the genetics community. Together …
Host genetic variation has a profound impact on immune responses mediating control of viral load in chronic gammaherpesvirus infection
EA Holt, CM Waytashek, KJ Sessions… - The Journal of …, 2023 - journals.aai.org
Chronic infection with the gammaherpesvirus EBV is a risk factor for several autoimmune
diseases, and poor control of EBV viral load and enhanced anti-EBV responses elevate this …
diseases, and poor control of EBV viral load and enhanced anti-EBV responses elevate this …
Divergent genetic regulation of nitric oxide production between C57BL/6J and wild-derived PWD/PhJ mice controls postactivation mitochondrial metabolism, cell …
JP Snyder, SK Gullickson, R del Rio-Guerra… - The Journal of …, 2022 - journals.aai.org
Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a
requirement for survival in DC subsets that express inducible NO synthase (Nos2) due to NO …
requirement for survival in DC subsets that express inducible NO synthase (Nos2) due to NO …
Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection
The response to infection is generally heterogeneous and diverse, with some individuals
remaining asymptomatic while others present with severe disease or a diverse range of …
remaining asymptomatic while others present with severe disease or a diverse range of …
and Eyal Amiel1# From the 1Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405 2Flow Cytometry and Cell Sorting Facility …
JP Snyder, SK Gullickson… - The Impact Of Nitric …, 2022 - search.proquest.com
Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a
requirement for survival in DC subsets that express inducible nitric oxide synthase (Nos2 …
requirement for survival in DC subsets that express inducible nitric oxide synthase (Nos2 …