Mouse models for immuno-oncology

M Bosenberg, ET Liu, IY Chun, K Palucka - Trends in Cancer, 2023 - cell.com
Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our
knowledge of in vivo mechanisms underlying treatment response as well as treatment …

Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation

L Amable, LA Ferreira Martins, R Pierre… - Nature …, 2023 - nature.com
Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production
profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c …

Which mouse multiparental population is right for your study? The Collaborative Cross inbred strains, their F1 hybrids, or the Diversity Outbred population

GR Keele - G3: Genes, Genomes, Genetics, 2023 - academic.oup.com
Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …

[HTML][HTML] Regulation of protein abundance in genetically diverse mouse populations

GR Keele, T Zhang, DT Pham, M Vincent, TA Bell… - Cell Genomics, 2021 - cell.com
Genetically diverse mouse populations are powerful tools for characterizing the regulation of
the proteome and its relationship to whole-organism phenotypes. We used mass …

Using the collaborative cross and diversity outbred mice in immunology

J Hackett, H Gibson, J Frelinger… - Current protocols, 2022 - Wiley Online Library
Abstract The Collaborative Cross (CC) and the Diversity Outbred (DO) stock mouse panels
are the most powerful murine genetics tools available to the genetics community. Together …

Host genetic variation has a profound impact on immune responses mediating control of viral load in chronic gammaherpesvirus infection

EA Holt, CM Waytashek, KJ Sessions… - The Journal of …, 2023 - journals.aai.org
Chronic infection with the gammaherpesvirus EBV is a risk factor for several autoimmune
diseases, and poor control of EBV viral load and enhanced anti-EBV responses elevate this …

Divergent genetic regulation of nitric oxide production between C57BL/6J and wild-derived PWD/PhJ mice controls postactivation mitochondrial metabolism, cell …

JP Snyder, SK Gullickson, R del Rio-Guerra… - The Journal of …, 2022 - journals.aai.org
Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a
requirement for survival in DC subsets that express inducible NO synthase (Nos2) due to NO …

Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection

JB Graham, JL Swarts, SR Leist, A Schäfer, TA Bell… - Iscience, 2024 - cell.com
The response to infection is generally heterogeneous and diverse, with some individuals
remaining asymptomatic while others present with severe disease or a diverse range of …

and Eyal Amiel1# From the 1Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405 2Flow Cytometry and Cell Sorting Facility …

JP Snyder, SK Gullickson… - The Impact Of Nitric …, 2022 - search.proquest.com
Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a
requirement for survival in DC subsets that express inducible nitric oxide synthase (Nos2 …