Control of protein stability by post-translational modifications
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …
regulatory domains of target proteins, which control a protein's stability. These regions …
mRNAs, proteins and the emerging principles of gene expression control
C Buccitelli, M Selbach - Nature Reviews Genetics, 2020 - nature.com
Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …
The degree to which protein abundances scale with mRNA levels and the implications in …
Deuterium‐and tritium‐labelled compounds: applications in the life sciences
J Atzrodt, V Derdau, WJ Kerr… - Angewandte chemie …, 2018 - Wiley Online Library
Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …
Proteome-wide mapping of short-lived proteins in human cells
Rapid protein degradation enables cells to quickly modulate protein abundance.
Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A …
Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A …
Global quantification of mammalian gene expression control
B Schwanhäusser, D Busse, N Li, G Dittmar… - Nature, 2011 - nature.com
Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental …
turnover of messenger RNAs and proteins. Although it is one of the most fundamental …
Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins
CM Fusco, K Desch, AR Dörrbaum, M Wang… - Nature …, 2021 - nature.com
Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …
A perspective on the kinetics of covalent and irreversible inhibition
JM Strelow - SLAS Discovery: Advancing Life Sciences R&D, 2017 - journals.sagepub.com
The clinical and commercial success of covalent drugs has prompted a renewed and more
deliberate pursuit of covalent and irreversible mechanisms within drug discovery. A covalent …
deliberate pursuit of covalent and irreversible mechanisms within drug discovery. A covalent …
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
A Mares, AH Miah, IED Smith, M Rackham… - Communications …, 2020 - nature.com
Abstract Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules
that can promote the rapid and selective proteasome-mediated degradation of intracellular …
that can promote the rapid and selective proteasome-mediated degradation of intracellular …
[HTML][HTML] Correlation of mRNA and protein in complex biological samples
The correlation between mRNA and protein abundances in the cell has been reported to be
notoriously poor. Recent technological advances in the quantitative analysis of mRNA and …
notoriously poor. Recent technological advances in the quantitative analysis of mRNA and …
The demographics of the ubiquitin system
The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …
protein degradation and signalling pathways. A key building block of a systems-level …