Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Lipophagy is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral
lipases. Chaperon-mediated autophagy (CMA) triggers lipid droplets (LDs) breakdown, to …

Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of
glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that …

The skeletal muscle (SkM) is the largest organ, which plays a vital role in controlling
musculature, locomotion, body heat regulation, physical strength, and metabolism of the …

Background and Purpose IL‐1β produced by macrophages via the NOD‐, LRR‐and pyrin
domain‐containing 3 (NLRP3) inflammasome, mediates the inflammatory crosstalk between …

Sarcopenia, characterized by a loss of muscle mass and strength with aging, is prevalent in
older adults. Although the exact mechanisms underlying sarcopenia are not fully …

Background and Purpose Skeletal muscle is the predominant site for glucose disposal and
fatty acid consumption. Emerging evidence indicates that the crosstalk between adipose …

Background The effects of some drugs, aging, cancers, and other diseases can cause
muscle wasting. Currently, there are no effective drugs for treating muscle wasting. In this …