The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Recently, the use of enantiomerically pure counteranions for the induction of asymmetry in
reactions proceeding through cationic intermediates has emerged as an exciting new …

Conspectus Asymmetric catalysis has been considered to be the most intriguing means for
building collections of functionalized optically active compounds. In particular, metal and …

A combination of NHC organocatalysis and transition-metal catalysis gives rise to
fundamentally new cooperative reactivity and enables the regio-and enantioselective …

Homogeneous gold catalysis has received growing attention over the past few years,
enabling the replacement of consolidated organic reactions with more simple, selective, and …

Sequential reactions, through the incorporation of several distinct transformations into one
single sequence, are one of the most powerful synthetic tools in modern organic chemistry …

The first catalytic asymmetric inverse‐electron‐demand (IED) oxa‐Diels–Alder reaction of
ortho‐quinone methides, generated in situ from ortho‐hydroxybenzyl alcohols, has been …

The first phosphoric acid-catalyzed asymmetric direct arylative reactions of 2-naphthols with
quinone derivatives have been developed, providing efficient access to a class of axially …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

Chiral indole derivatives are an intriguing class of heterocyclic compounds; their structural
motifs are frequently found in natural products and synthetic compounds with significant …