Apparent changes in the epidemiology and severity of multiple sclerosis

N Koch-Henriksen, M Magyari - Nature Reviews Neurology, 2021 - nature.com
Multiple sclerosis (MS) is an immunological disease that causes acute inflammatory lesions
and chronic inflammation in the CNS, leading to tissue damage and disability. As awareness …

Multiple sclerosis: clinical aspects

J Oh, A Vidal-Jordana, X Montalban - Current opinion in …, 2018 - journals.lww.com
A number of recent advances have been made in the clinical diagnosis and prognostication
of multiple sclerosis patients. Future research will enable the development of more accurate …

Role of B cells in multiple sclerosis and related disorders

G Comi, A Bar‐Or, H Lassmann, A Uccelli… - Annals of …, 2021 - Wiley Online Library
The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …

Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the Guideline Development, Dissemination …

A Rae-Grant, GS Day, RA Marrie, A Rabinstein… - Neurology, 2018 - AAN Enterprises
Objective To develop recommendations for disease-modifying therapy (DMT) for multiple
sclerosis (MS). Methods A multidisciplinary panel developed DMT recommendations …

MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines

M Filippi, MA Rocca, O Ciccarelli, N De Stefano… - The Lancet …, 2016 - thelancet.com
In patients presenting with a clinically isolated syndrome, MRI can support and substitute
clinical information in the diagnosis of multiple sclerosis by showing disease dissemination …

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

AJ Thompson, BL Banwell, F Barkhof… - The Lancet …, 2018 - thelancet.com
The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in
research and clinical practice. Scientific advances in the past 7 years suggest that they might …

Molecular biomarkers in multiple sclerosis

T Ziemssen, K Akgün, W Brück - Journal of neuroinflammation, 2019 - Springer
Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous
system presenting with significant inter-and intraindividual heterogeneity. However, the …

Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis

D Rotstein, X Montalban - Nature Reviews Neurology, 2019 - nature.com
Personalized treatment is ideal for multiple sclerosis (MS) owing to the heterogeneity of
clinical features, but current knowledge gaps, including validation of biomarkers and …

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

The multiple sclerosis prodrome

N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …