Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms. Although AMPs have been essentially studied and developed as potential …

Permeation of the cell membrane leading to cell death is a mechanism used by a large
number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one …

Water‐membrane soluble protein and peptide toxins are used in the defense and offense
systems of all organisms, including plants and humans. A major group includes …

In spite of great advances in cancer therapy, there is considerable current interest in
developing anticancer agents with a new mode of action because of the development of …

Melittin is a prototype of the ubiquitous antimicrobial peptides that induce pores in
membranes. It is commonly used as a molecular device for membrane permeabilization …

Boman HG (Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm,
Sweden). Antibacterial peptides: basic facts and emerging concepts (Review). J Intern Med …

During the last two decades cationic amphiphilic peptides and peptide sequences (CAPs)
with cancer-selective toxicity have appeared. Based on their spectrum of anticancer activity …

The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to
develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides …

The influence of ion composition, pH, and peptide concentration on the conformation and
activity of the 37-residue human antibacterial peptide LL-37 has been studied. At micromolar …

The argument and experimental evidence are presented for a two-state model that explains
the action of both helical and β-sheet antimicrobial peptides after they bind to the plasma …