Synthetic macromolecular antimicrobials have shown efficacy in the treatment of multidrug
resistant (MDR) pathogens. These synthetic macromolecules, inspired by Nature's …

The conformational restriction (rigidification) of a flexible ligand has often been a commonly
used strategy in drug design, as it can minimize the entropic loss associated with the ligand …

Macrocyclic compounds are of growing interest because of their natural existence, their
interesting biological, physicochemical properties, and potential applications in medicine. 1 …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

Resistance to aminoglycoside antibiotics has had a profound impact on clinical practice.
Despite their powerful bactericidal activity, aminoglycosides were one of the first groups of …

In the last few years, antibiotic resistance and, analogously, anticancer drug resistance have
increased considerably, becoming one of the main public health problems. For this reason, it …

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available
antibiotics, and requires new approaches to antibiotic discovery and development …

Shortly after the discovery of the first antibiotics, bacterial resistance began to emerge. Many
mechanisms give rise to resistance; the most prevalent mechanism of resistance to the …

Herein is described the identification of RNA internal loops that bind to derivatives of
neomycin B, neamine, tobramycin, and kanamycin A. RNA loop− ligand partners were …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …