Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

Nuclear receptors have generated substantial interest in the past decade as potential
therapeutic targets for the treatment of neurodegenerative disorders. Despite years of effort …

Disruption of the gut‐brain axis in Parkinson's disease (PD) may lead to motor symptoms
and PD pathogenesis. Recently, the neuroprotective potential of different PPARδ‐agonists …

Omega-9 monounsaturated fatty acids (ω-9 MUFAs) are a group of unsaturated fatty acids
with a unique double bond in the 9th position at the end of the methyl group terminal, having …

Peroxisome proliferator-activated receptors (PPARs) are a class of transcription factors that
belong to the nuclear hormone receptor superfamily, and their activities are dependent on …

Background Alzheimer's disease (AD) is a multifactorial disorder associated with the
accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into …

Neurodegenerative diseases are characterized by a progressive loss of neurons that leads
to a broad range of disabilities, including severe cognitive decline and motor impairment, for …

In this review study, we focus on potential benefits of the transcription factor PPARδ and its
ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's …