Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T Xie… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Short-chain fatty acids: linking diet, the microbiome and immunity

ER Mann, YK Lam, HH Uhlig - Nature Reviews Immunology, 2024 - nature.com
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

Adoptive Treg therapy with metabolic intervention via perforated microneedles ameliorates psoriasis syndrome

W Zhang, Y Chen, Z Zhao, H Zheng, S Wang, Z Liao… - Science …, 2023 - science.org
Regulatory T (Treg) cells underlie multiple autoimmune disorders and potentialize an anti-
inflammation treatment with adoptive cell therapy. However, systemic delivery of cellular …

[HTML][HTML] Gut microbial metabolite butyrate and its therapeutic role in inflammatory bowel disease: a literature review

N Recharla, R Geesala, XZ Shi - Nutrients, 2023 - mdpi.com
Background and objective: Inflammatory bowel disease (IBD), including Crohn's disease
and ulcerative colitis, is a chronic inflammatory disorder characterized by aberrant immune …

Delivery of short chain fatty acid butyrate to overcome Fusobacterium nucleatum-induced chemoresistance

L Chen, R Zhao, Z Kang, Z Cao, N Liu, J Shen… - Journal of Controlled …, 2023 - Elsevier
The gut microbiota is closely associated with the progression of colorectal cancer (CRC) in
which Fusobacterium nucleatum (F. nucleatum) was found to induce cancer resistance to …

An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease

X Fan, Z Zhang, W Gao, Q Pan, K Luo, B He, Y Pu - ACS nano, 2023 - ACS Publications
Colonic epithelial damage and dysregulated immune response are crucial factors in the
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted …

[PDF][PDF] Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food

AM Kemter, RT Patry, J Arnold, LA Hesser, E Campbell… - Cell reports, 2023 - cell.com
The increasing prevalence of food allergies has been linked to reduced commensal
microbial diversity. In this article, we describe two features of allergy-protective Clostridia …

[PDF][PDF] Glycosylation-modified antigens as a tolerance-inducing vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

S Cao, CD Maulloo, MM Raczy, M Sabados… - Cell Reports …, 2024 - cell.com
The only FDA-approved oral immunotherapy for a food allergy provides protection against
accidental exposure to peanuts. However, this therapy often causes discomfort or side …

Contributions of the early-life microbiome to childhood atopy and asthma development

H Steininger, J Moltzau-Anderson, SV Lynch - Seminars in Immunology, 2023 - Elsevier
The rapid rise in atopy and asthma in industrialized nations has led to the identification of
early life environmental factors that promote these conditions and spurred research into how …

In vitro assessment of the effect of four polysaccharides on intestinal bacteria of mice with colitis

S Zhang, Y Sun, Q Nie, J Hu, W Su, Z Guo… - Food …, 2023 - Wiley Online Library
Polysaccharides are typically resistant to digestion in the gastrointestinal tract and are
instead degraded by gut microbiota in the colon. As such, they are commonly employed as …