Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …

Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …

The filamentous 'Pf'bacteriophages of Pseudomonas aeruginosa play roles in biofilm
formation and virulence, but mechanisms governing Pf prophage activation in biofilms are …

The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged
mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and …

CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their
misregulation contributes to cancer, neurodegenerative diseases, and sleep phase …

Abstract KEOPS (K inase, E ndopeptidase and O ther P roteins of S mall size) is a five-
subunit protein complex that is highly conserved in eukaryotes and archaea and is essential …

All living organisms must develop mechanisms to cope with and adapt to new environments.
The transition of plants from aquatic to terrestrial environment provided new opportunities for …