[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …
[HTML][HTML] NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
[HTML][HTML] Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated …
progression that suggest diverse host immune responses. We performed an integrated …
Interferon-stimulated genes: what do they all do?
JW Schoggins - Annual review of virology, 2019 - annualreviews.org
In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …
[PDF][PDF] DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity
Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency
(dMMR) are proposed as the major contributor to the high objective response rate in anti-PD …
(dMMR) are proposed as the major contributor to the high objective response rate in anti-PD …
[HTML][HTML] Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy.
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …
Previously, we demonstrated a potent IFN immunogenicity of nucleic acid–containing (NA …
[HTML][HTML] Lessons in self-defence: inhibition of virus entry by intrinsic immunity
S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …
[HTML][HTML] Host immune response to influenza A virus infection
Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …
[PDF][PDF] Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
M Puray-Chavez, KM LaPak, TP Schrank, JL Elliott… - Cell Reports, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …