The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK).
GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of …

Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-
controlling step responsible for insulin stimulation of glycogen synthesis is unknown. We …

Fasting hypoglycemia is a severe and incompletely understood symptom of various inborn
errors of metabolism (IEM). Precision-cut liver slices (PCLS) represent a promising model for …

Liver glucose metabolism is dependent on glucokinase activity. Glucokinase expression is
transcriptionally regulated by hormones and metabolites of glucose, and glucokinase activity …

Food manufacturers are under increasing pressure to limit the amount of free sugars in their
products. Many have reformulated products to replace sucrose, glucose and fructose with …

Glucagon's ability to promote hepatic glucose production has been known for over a century,
with initial observations touting this hormone as a diabetogenic agent. However, glucagon …

The glucokinase regulator (GCKR) gene encodes an inhibitor of the glucokinase enzyme
(GCK), found only in hepatocytes and responsible for glucose metabolism. A common …

Introduction: Glucokinase (GK) is a key regulator of glucose homeostasis, and development
of small molecule activators of this enzyme represents a promising new approach for the …