Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies

BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …

Design of pressure-driven microfluidic networks using electric circuit analogy

KW Oh, K Lee, B Ahn, EP Furlani - Lab on a Chip, 2012 - pubs.rsc.org
This article reviews the application of electric circuit methods for the analysis of pressure-
driven microfluidic networks with an emphasis on concentration-and flow-dependent …

The origins and the future of microfluidics

GM Whitesides - nature, 2006 - nature.com
The manipulation of fluids in channels with dimensions of tens of micrometres—microfluidics—
has emerged as a distinct new field. Microfluidics has the potential to influence subject areas …

Cells on chips

J El-Ali, PK Sorger, KF Jensen - Nature, 2006 - nature.com
Microsystems create new opportunities for the spatial and temporal control of cell growth
and stimuli by combining surfaces that mimic complex biochemistries and geometries of the …

Concentration gradient generation methods based on microfluidic systems

X Wang, Z Liu, Y Pang - RSC advances, 2017 - pubs.rsc.org
Various concentration gradient generation methods based on microfluidic systems are
summarized in this paper. The review covers typical structural characteristics, gradient …

Micro total analysis systems. Latest advancements and trends

PS Dittrich, K Tachikawa, A Manz - Analytical chemistry, 2006 - ACS Publications
The area of micro total analysis systems (μTAS), also called “lab on a chip”, miniaturized or
microfluidic analysis systems, is a rapidly developing field. During the last several years, we …

Biomolecular gradients in cell culture systems

TM Keenan, A Folch - Lab on a Chip, 2008 - pubs.rsc.org
Biomolecule gradients have been shown to play roles in a wide range of biological
processes including development, inflammation, wound healing, and cancer metastasis …

Biological applications of microfluidic gradient devices

S Kim, HJ Kim, NL Jeon - Integrative Biology, 2010 - academic.oup.com
Molecular gradients play an important role in diverse physiological and pathological
phenomena such as immune response, wound healing, development and cancer …

Review on cell mechanics: experimental and modeling approaches

ML Rodriguez, PJ McGarry… - Applied …, 2013 - asmedigitalcollection.asme.org
The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology

NT Nguyen, SAM Shaegh, N Kashaninejad… - Advanced drug delivery …, 2013 - Elsevier
Lab-on-a-chip technology is an emerging field evolving from the recent advances of micro-
and nanotechnologies. The technology allows the integration of various components into a …