Pharmaceutical cocrystals: a rising star in drug delivery applications

P Panzade, A Wagh, P Harale… - Journal of drug …, 2024 - Taylor & Francis
Pharmaceutical cocrystals, owing to their manifold applications, are acting as bridge
between drug discovery and pharmaceutical product development. The ability to scale up …

Advances in solvent based cocrystallization: Bridging the gap between theory and practice

S Sarangi, PN Remya, N Damodharan - Journal of Drug Delivery Science …, 2024 - Elsevier
A common tactic in materials science and pharmaceuticals is cocrystallization, which
synthesises multi-component crystalline materials with unique physicochemical …

Repurposing of Antifungal Drug Flucytosine/Flucytosine Cocrystals for Anticancer Activity against Prostate Cancer Targeting Apoptosis and Inflammatory Signaling …

M Kanagavel, RM Sparjan Samuvel… - Molecular …, 2024 - ACS Publications
This study aimed to repurpose the antifungal drug flucytosine (FCN) for anticancer activity
together with cocrystals of nutraceutical coformers sinapic acid (SNP) and syringic acid …

Sulfonate–Pyridinium Ionic Cocrystal Solvates: Improved Material and Antimicrobial Properties

I Ahmad, AA Malik, S Ahmad, AA Dar - Crystal Growth & Design, 2024 - ACS Publications
Organic cocrystals are attracting the attention of researchers from diverse fields and are the
focus of interdisciplinary research. Cocrystals provide a convenient opportunity to realize the …

Reaction crystallization method based on deep eutectic solvents: A novel, green and efficient cocrystal synthesis approach

XL Dai, YH Yao, JF Zhen, W Gao, JM Chen… - Chinese Chemical …, 2024 - Elsevier
Reaction crystallization method is a common cocrystal synthesis approach attributed to the
advantage of avoiding individual crystallization of insoluble components, but faces the …

Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin

D Li, W Chen, L Zhou, L Xu, F He, JYY Heng… - Crystal Growth & …, 2024 - ACS Publications
Understanding drug cocrystal formation and its competitive mechanism is important for
improving the physicochemical properties of drugs. In this article, the cocrystal formation of …

Determination of the Asymmetric Ternary Phase Diagram and Preparation of Theophylline–Isonicotinamide Cocrystals

W Liu, X Yang, S Wang, H Wang, B Zhang… - Crystal Growth & …, 2024 - ACS Publications
The solid–liquid phase equilibrium data of theophylline and isonicotinamide in selected
solvents (isopropanol, N, N-dimethylformamide, and n-pentanol) were determined by using …

Ternary phase diagram and investigation of slurry conversion of 1: 1 sulfamethazine-acetylsalicylic acid cocrystal

A Saha, SV Dalvi, AA Dar, JV Parambil - Chemical Engineering Research …, 2024 - Elsevier
Abstract Successful production of 1: 1 sulfamethazine-acetylsalicylic acid (SMZ-ASA)
cocrystal was achieved through slow solvent evaporation, liquid-assisted grinding, and …

Stoichiometric Diversity of Caffeine and 4-Hydroxybenzoic Acid Cocrystals in Batchelor Vortex Flow

ZH Li, WS Kim - Crystal Growth & Design, 2024 - ACS Publications
In this study, we explored the influence of fluid flow on the stoichiometric diversity in
cocrystal formation. The cocrystallization of caffeine (CAF) with 4-hydroxybenzoic acid (4 …

[HTML][HTML] Supramolecular architectures in multicomponent crystals of imidazole-based drugs and trithiocyanuric acid

A Ben, M Hoelm, L Chęcińska - Structural Science, 2024 - journals.iucr.org
The structures of three multicomponent crystals formed with imidazole-based drugs, namely
metronidazole, ketoconazole and miconazole, in conjunction with trithiocyanuric acid are …