The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …

Ground squirrels exemplify one of the most extreme forms of mammalian hibernation and a
convenient model for studying its mechanisms. Their thermoregulatory system demonstrates …

Pyroglutamylated RF-amide peptide (QRFP) is a peptide hormone with a C-terminal RF-
amide motif. QRFP selectively activates a class A G-protein-coupled receptor (GPCR) …

Optogenetics is a powerful tool for manipulating neuronal activity by light illumination with
high temporal and spatial resolution. Anion-channelrhodopsins (ACRs) are light-gated …

Pyroglutamylated RF amide peptide (QRFP) is a type of peptide hormone with a C-terminal
RF-amide motif. QRFP selectively activates class-A categorized GPCR, GPR103 to exert …

Mus musculus enters a torpid state in response to caloric restriction in sub-thermoneutral
ambient temperatures. This torpid state is characterized by an adaptive and controlled …

How mammals enter hypometabolic states, known as torpor and hibernation, has fascinated
researchers for decades, but the central control mechanisms that regulate entry into torpor …

In mammals, males execute a stereotypical and organized sequence of sexual behaviours,
such as mounting, intromission, and ejaculation, to successfully complete copulation …

We present a protocol for inducing a hibernation-like state in free-moving mice using
optogenetics. We have recently developed an optogenetic technique utilizing modified …

Pyroglutamylated RF amide peptide (QRFP) is a type of peptide hormone with a C-terminal
RF-amide motif. QRFP selectively activates class-A categorized GPCR, GPR103 to exert …