[HTML][HTML] Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance
S Almuraikhy, W Kafienah, M Bashah, I Diboun… - Diabetologia, 2016 - Springer
Aims/hypothesis A subset of obese individuals remains insulin sensitive by mechanisms as
yet unclear. The hypothesis that maintenance of normal subcutaneous (SC) adipogenesis …
yet unclear. The hypothesis that maintenance of normal subcutaneous (SC) adipogenesis …
[HTML][HTML] Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels
C Li, M Deng, J Hu, X Li, L Chen, Y Ju, J Hao, S Meng - Oncotarget, 2016 - ncbi.nlm.nih.gov
Persistent inflammation in chronic hepatitis plays a major role in the development of
hepatocellular carcinoma (HCC). In this study, the major inflammatory cytokines expressed …
hepatocellular carcinoma (HCC). In this study, the major inflammatory cytokines expressed …
Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics
Human serum paraoxonase (PON1, EC 3.1. 8.1.) is a high-density lipid (HDL)-associated,
calcium-dependent enzyme; its physiological substrates are not known. In this study, a new …
calcium-dependent enzyme; its physiological substrates are not known. In this study, a new …
Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia
P Diamanti, CV Cox, JP Moppett… - Blood, The Journal of the …, 2013 - ashpublications.org
Approximately 20% of children with acute lymphoblastic leukemia (ALL) relapse because of
failure to eradicate the disease. Current drug efficacy studies focus on reducing leukemia …
failure to eradicate the disease. Current drug efficacy studies focus on reducing leukemia …
A critical role for the Sp1-binding sites in the transforming growth factor-β-mediated inhibition of lipoprotein lipase gene expression in macrophages
Increasing evidence suggests that the cytokine transforming growth factor-β (TGF-β) inhibits
the development of atherosclerosis. The lipoprotein lipase (LPL) enzyme expressed by …
the development of atherosclerosis. The lipoprotein lipase (LPL) enzyme expressed by …
[HTML][HTML] Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic …
A Wróblewski, J Strycharz, E Świderska… - International Journal of …, 2021 - mdpi.com
Adipokines secreted by hypertrophic visceral adipose tissue (VAT) instigate low-grade
inflammation, followed by hyperglycemia (HG)-related metabolic disorders. The latter may …
inflammation, followed by hyperglycemia (HG)-related metabolic disorders. The latter may …
SP1 and USF differentially regulate ADAMTS1 gene expression under normoxic and hypoxic conditions in hepatoma cells
SA Turkoglu, F Kockar - Gene, 2016 - Elsevier
ADAM metallopeptidase with thrombospondin type I motif, 1 (ADAMTS1) that has both
antiangiogenic and aggrecanase activity was dysregulated in many pathophysiologic …
antiangiogenic and aggrecanase activity was dysregulated in many pathophysiologic …
Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells
Up-regulation of ADAMTS genes with proinflammatory cytokines is important for some
pathological conditions such as osteoarthritis (OA) that is a disease based on ECM …
pathological conditions such as osteoarthritis (OA) that is a disease based on ECM …
Interleukin-6 inhibits human peroxisome proliferator activated receptor alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes
CH Chew, GS Chew, N Najimudin… - The international journal …, 2007 - Elsevier
Peroxisome proliferator activated receptor alpha has been implicated as a regulator of acute
phase response genes in hepatocytes. Interleukin-6 is widely known as a major cytokine …
phase response genes in hepatocytes. Interleukin-6 is widely known as a major cytokine …
Increased expression of CCAAT/enhancer‐binding protein beta in proliferative inflammatory atrophy of the prostate: Relation with the expression of COX‐2, the …
W Wang, A Bergh, JE Damber - The Prostate, 2007 - Wiley Online Library
BACKGROUND Proliferative inflammatory atrophy (PIA) in the prostate has been proposed
to be a precursor to prostate cancer. CCAAT/enhancer‐binding protein beta (C/EBPβ) is an …
to be a precursor to prostate cancer. CCAAT/enhancer‐binding protein beta (C/EBPβ) is an …