B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival
factor which supports autoreactive B cells and prevents their deletion. BAFF expression is …

Nuclear factor κB (NF-κB) is a family of inducible transcription factors that plays a vital role in
different aspects of immune responses. NF-κB is normally sequestered in the cytoplasm as …

Systemic lupus erythematosus (SLE) is characterized by multisystem immune-mediated
injury in the setting of autoimmunity to nuclear antigens. The clinical heterogeneity of SLE …

Systemic lupus erythematosus (SLE) is a complex clinical syndrome, elements of which
remain poorly understood. Although recognized over 140 years ago when Kaposi recorded …

Neuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a
severe and troubling manifestation of the disease that heavily impacts patient's health …

The rate of pediatric inflammatory bowel disease (IBD) has been increasing over the last
decade and this increase has occurred most rapidly in the youngest children diagnosed< 6 …

Objective Knowledge of interleukin‐38 (IL‐38), formerly IL‐1 family member 10, is sparse,
but Il1f10 polymorphisms are associated with inflammatory diseases, and recombinant IL‐38 …

The introduction of corticosteroids and later, cyclophosphamide dramatically improved
survival in patients with proliferative lupus nephritis, and combined administration of these …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by
the development of autoantibodies to nuclear antigens and inflammatory responses …