Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

DS Novikov, E Fieremans, SN Jespersen… - NMR in …, 2019 - Wiley Online Library
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

[HTML][HTML] Investigating white matter fibre density and morphology using fixel-based analysis

DA Raffelt, JD Tournier, RE Smith, DN Vaughan… - Neuroimage, 2017 - Elsevier
Voxel-based analysis of diffusion MRI data is increasingly popular. However, most white
matter voxels contain contributions from multiple fibre populations (often referred to as …

[HTML][HTML] Multi-compartment microscopic diffusion imaging

E Kaden, ND Kelm, RP Carson, MD Does… - NeuroImage, 2016 - Elsevier
This paper introduces a multi-compartment model for microscopic diffusion anisotropy
imaging. The aim is to estimate microscopic features specific to the intra-and extra-neurite …

[HTML][HTML] Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro …

SY Huang, T Witzel, B Keil, A Scholz, M Davids, P Dietz… - NeuroImage, 2021 - Elsevier
The first phase of the Human Connectome Project pioneered advances in MRI technology
for mapping the macroscopic structural connections of the living human brain through the …

Studying neuroanatomy using MRI

JP Lerch, AJW Van Der Kouwe, A Raznahan… - Nature …, 2017 - nature.com
The study of neuroanatomy using imaging enables key insights into how our brains function,
are shaped by genes and environment, and change with development, aging and disease …

[HTML][HTML] Noninvasive quantification of axon radii using diffusion MRI

J Veraart, D Nunes, U Rudrapatna, E Fieremans… - elife, 2020 - elifesciences.org
Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the
timing and synchronization of neural activation. Noninvasive measurement of axon radii …

Modelling white matter with spherical deconvolution: How and why?

F Dell'Acqua, JD Tournier - NMR in Biomedicine, 2019 - Wiley Online Library
Since the realization that diffusion MRI can probe the microstructural organization and
orientation of biological tissue in vivo and non‐invasively, a multitude of diffusion imaging …

Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI

DK Jones, DC Alexander, R Bowtell, M Cercignani… - NeuroImage, 2018 - Elsevier
The key component of a microstructural diffusion MRI 'super-scanner'is a dedicated high-
strength gradient system that enables stronger diffusion weightings per unit time compared …

[HTML][HTML] Diffusion-weighted imaging: recent advances and applications

E Martinez-Heras, F Grussu, F Prados, E Solana… - Seminars in Ultrasound …, 2021 - Elsevier
Quantitative diffusion imaging techniques enable the characterization of tissue
microstructural properties of the human brain “in vivo”, and are widely used in neuroscientific …