Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

Since the first report of p53 as a non-histone target of a histone acetyltransferase (HAT),
there has been a rapid proliferation in the description of new non-histone targets of HATs. Of …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor
Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in …

Loss of p53 function occurs during the development of most, if not all, tumour types. This
paves the way for genomic instability, tumour-associated changes in metabolism …

The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the
absence of cellular stress, the p53 protein is maintained at low steady-state levels and …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …