Apelin is an endogenous ligand of G protein-coupled receptor APJ. It is extensively
expressed in many tissues such as heart, liver, and kidney, especially in lung tissue. A …

Monitoring of cell-cell communication in multicellular organisms is fundamental to
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …

Bioluminescence imaging (BLI), an optical preclinical imaging modality, is an invaluable
imaging modality due to its low-cost, high throughput, fast acquisition times, and functional …

To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and
acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms …

It has been suggested that new beta cells can arise from specific populations of adult
pancreatic progenitors or facultative stem cells. However, their existence remains …

Background: The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process
contributed by the accumulation of molecular alterations. We identified Apelin (APLN) as an …

Cancer is a disease that seriously endangers human health and is mainly characterized by
a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of …

Glioblastoma (GBM) present with an abundant and aberrant tumor neo-vasculature. While
rapid growth of solid tumors depends on the initiation of tumor angiogenesis, GBM also …

During angiogenesis, vascular tip cells guide nascent vascular sprouts to form a vascular
network. Apelin, an agonist of the G protein–coupled receptor Aplnr, is enriched in vascular …

Antiangiogenic therapy of glioblastoma (GBM) with bevacizumab, a VEGFA-blocking
antibody, may accelerate tumor cell invasion and induce alternative angiogenic pathways …