Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

AP Klein - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …

Advances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis

J Cai, H Chen, M Lu, Y Zhang, B Lu, L You, T Zhang… - Cancer letters, 2021 - Elsevier
Pancreatic cancer is a malignancy with poor prognosis and high mortality. The recent
increase in pancreatic cancer incidence and mortality has resulted in an increased number …

[HTML][HTML] A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories

D Placido, B Yuan, JX Hjaltelin, C Zheng, AD Haue… - Nature medicine, 2023 - nature.com
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes,
indicating a pronounced need for early detection. In this study, we applied artificial …

[HTML][HTML] Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

Pancreatic cancer: a review of risk factors, diagnosis, and treatment

ZY Zhao, W Liu - Technology in cancer research & treatment, 2020 - journals.sagepub.com
This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

Genome-wide association studies of cancer: current insights and future perspectives

A Sud, B Kinnersley, RS Houlston - Nature Reviews Cancer, 2017 - nature.com
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Obesity, inflammation, and cancer

T Deng, CJ Lyon, S Bergin, MA Caligiuri… - Annual Review of …, 2016 - annualreviews.org
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …

Pancreatic cancer biology and genetics from an evolutionary perspective

A Makohon-Moore, CA Iacobuzio-Donahue - Nature Reviews Cancer, 2016 - nature.com
Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …

Recent progress in pancreatic cancer

CL Wolfgang, JM Herman, DA Laheru… - CA: a cancer journal …, 2013 - Wiley Online Library
Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

[PDF][PDF] Beyond GWASs: illuminating the dark road from association to function

SL Edwards, J Beesley, JD French… - The American Journal of …, 2013 - cell.com
Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …