Cyclin-dependent kinases as coregulators of inflammatory gene expression
ML Schmitz, M Kracht - Trends in pharmacological sciences, 2016 - cell.com
Cyclin-dependent kinases (CDKs) exert a variety of functions through regulation of the cell
cycle and gene expression, thus implicating them in diverse biological processes. Recent …
cycle and gene expression, thus implicating them in diverse biological processes. Recent …
Targeting cyclin-dependent kinases in anti-neoplastic therapy
C Bruyère, L Meijer - Current opinion in cell biology, 2013 - Elsevier
Cell cycle progression is controlled by sequential activation of cyclin-dependent kinases
(CDKs), which are often deregulated in cancer. Consequently numerous pharmacological …
(CDKs), which are often deregulated in cancer. Consequently numerous pharmacological …
Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
P Chandrakesan, J Yao, D Qu, R May, N Weygant… - Molecular Cancer, 2017 - Springer
Background More than 80% of intestinal neoplasia is associated with the adenomatous
polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is …
polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is …
The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells
JC Godbersen, LA Humphries, OV Danilova… - Clinical cancer …, 2014 - AACR
Background: Stromal-mediated signaling enhances NF-κB pathway activity in chronic
lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance …
lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance …
Cyclin-dependent kinase-9 is a therapeutic target in MYC-expressing diffuse large B-cell lymphoma
Deregulation of the MYC transcription factor is a key driver in lymphomagenesis. MYC
induces global changes in gene expression that contribute to cell growth, proliferation, and …
induces global changes in gene expression that contribute to cell growth, proliferation, and …
Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease
AK Mittal, NK Chaturvedi, KJ Rai… - Molecular …, 2014 - Springer
Chronic lymphocytic leukemia (CLL) cells survive longer in vivo than in vitro, suggesting that
the tissue microenvironment provides prosurvival signals to tumor cells. Primary and …
the tissue microenvironment provides prosurvival signals to tumor cells. Primary and …
Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia
MTS Williams, Y Yousafzai, C Cox… - Blood, The Journal …, 2014 - ashpublications.org
Genome-wide association studies have consistently implicated the interleukin-15 (IL-15)
gene in acute lymphoblastic leukemia (ALL) biology, including associations with disease …
gene in acute lymphoblastic leukemia (ALL) biology, including associations with disease …
O-GlcNAcylation in chronic lymphocytic leukemia and other blood cancers
DE Spaner - Frontiers in immunology, 2021 - frontiersin.org
In the past decade, aberrant O-GlcNAcylation has emerged as a new hallmark of cancer. O-
GlcNAcylation is a post-translational modification that results when the amino-sugar β-DN …
GlcNAcylation is a post-translational modification that results when the amino-sugar β-DN …
[HTML][HTML] Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer
Activation of CDK2 in triple negative breast cancer (TNBC) can contribute to non-canonical
phosphorylation of a TGFβ signaling component, Smad3, promoting cell proliferation and …
phosphorylation of a TGFβ signaling component, Smad3, promoting cell proliferation and …
Targeted therapy in chronic lymphocytic leukemia: past, present, and future
AV Danilov - Clinical therapeutics, 2013 - Elsevier
Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the
western world. Recent advances in understanding the biology of B-cell malignancies have …
western world. Recent advances in understanding the biology of B-cell malignancies have …