Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

Cancer develops from normal tissues through the accumulation of genetic alterations that
act in concert to confer malignant phenotypes. Although we have now identified some of the …

Periodontitis is a chronic disease that begins with a period of inflammation of the supporting
tissues of the teeth table and then progresses, destroying the tissues until loss of the teeth …

The reconstruction of skeletal muscle tissue either lost by traumatic injury or tumor ablation
or functional damage due to myopathies is hampered by the lack of availability of functional …

Stem cells are located throughout the adult body of higher organisms, supporting a
continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and …

With age, there is a gradual decline in the regenerative properties of most tissues due to a
combination of age-dependent changes in tissue-specific stem cells and in the …

Abstract Development of a multicellular organism is accomplished through a series of events
that are preprogrammed in the genome. These events encompass cellular proliferation …

methods. HCECs were subjected to a sphere-forming assay in which spheres floated in
serum-free medium containing growth factors. To promote differentiation, the isolated sphere …

After peripheral nerve injury, the number of sensory neurons in the adult dorsal root ganglia
(DRG) is initially reduced but recovers to a normal level several months later. The …

DNA damage-driven genome instability underlies the diversity of life forms generated by the
evolutionary process but is detrimental to the somatic cells of individual organisms. The …