Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form
the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate …

Cell migration is a vital and dynamic process required for the development of multicellular
organisms and for immune system responses, tissue renewal and wound healing in adults. It …

Cells and tissues sense, respond to and translate mechanical forces into biochemical
signals through mechanotransduction, which governs individual cell responses that drive …

Cell mechanics is crucial for a wide range of cell functions, including proliferation, polarity,
migration and differentiation. Cells sense external physical cues and translate them into a …

The impaired ability of the heart to relax and stretch to accommodate venous return is
generally understood to represent a state of “diastolic dysfunction” and often described …

Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic
network through protein-protein interactions providing an effective mechanochemical …

Abstract Small Heat Shock Proteins are considered as the first line of defense when
proteostasis fails. Among them, αB-crystallin is expressed in striated muscles in which it …

Cellular adhesion and migration are key functions that are disrupted in numerous diseases.
We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell …

Liquid and elastic behaviours of tissues drive their morphology and response to the
environment. They appear as the first insight into tissue mechanics. We explore the role of …

The giant muscle protein titin is a major contributor to passive force; however, its role in
active force generation is unresolved. Here, we use a novel titin-cleavage (TC) mouse …