Currently, cancer is one of the main research topics, due to its high incidence and drug
resistance to existing anti-cancer drugs. Formononetin, a natural product with …

Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …

Abstract Mitochondrial malic enzyme 2 (ME2), which catalyzes the conversion of malate to
pyruvate, is frequently upregulated during tumorigenesis and is a potential target for cancer …

Reprogrammed metabolism is key biochemical characteristic of malignant cells, which
represents one of the emerging hallmarks of cancer. Currently, there is rising contemplation …

Myocardial infarction (MI) contributes to an increased risk of incident heart failure and
sudden death, but there is still a lack of effective treatment in clinic. Recently, growing …

It is well established that cancer cells acquire energy via the Warburg effect and oxidative
phosphorylation. Citrate is considered to play a crucial role in cancer metabolism by virtue of …

Abstract Human mitochondrial NAD (P)+-dependent malic enzyme (ME2) is well-known for
its role in cell metabolism, which may be involved in cancer or epilepsy. We present potent …

Pyruvate kinase (PK), a key enzyme that determines glycolytic activity, has been known to
support the metabolic phenotype of tumor cells, and specific pyruvate kinase isoform M2 …

Tooth development is a complex process that is tightly controlled by circadian rhythm.
Melatonin (MT) is a major hormonal regulator of the circadian rhythm, and influences dentin …

Metastasis is the leading cause of breast cancer‐related deaths and is often driven by
invasion and cancer‐stem like cells (CSCs). Both the CSC phenotype and invasion are …