Peptide-based vaccine for cancer therapies
L Buonaguro, M Tagliamonte - Frontiers in Immunology, 2023 - frontiersin.org
Different strategies based on peptides are available for cancer treatment, in particular to
counter-act the progression of tumor growth and disease relapse. In the last decade, in the …
counter-act the progression of tumor growth and disease relapse. In the last decade, in the …
AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Abstract Machine learning and in particular deep learning (DL) are increasingly important in
mass spectrometry (MS)-based proteomics. Recent DL models can predict the retention …
mass spectrometry (MS)-based proteomics. Recent DL models can predict the retention …
Unlocking the potential of microfluidics in mass spectrometry-based immunopeptidomics for tumor antigen discovery
The identification of tumor-specific antigens (TSAs) is critical for developing effective cancer
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …
[HTML][HTML] Proteomic discovery of chemical probes that perturb protein complexes in human cells
Most human proteins lack chemical probes, and several large-scale and generalizable small-
molecule binding assays have been introduced to address this problem. How compounds …
molecule binding assays have been introduced to address this problem. How compounds …
Immune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
A Nelde, H Schuster, JS Heitmann, J Bauer… - Blood Cancer …, 2023 - AACR
Therapy-resistant leukemia stem and progenitor cells (LSC) are a main cause of acute
myeloid leukemia (AML) relapse. LSC-targeting therapies may thus improve outcome of …
myeloid leukemia (AML) relapse. LSC-targeting therapies may thus improve outcome of …
Optimized liquid and gas phase fractionation increases HLA-peptidome coverage for primary cell and tissue samples
MS is the most effective method to directly identify peptides presented on human leukocyte
antigen (HLA) molecules. However, current standard approaches often use 500 million or …
antigen (HLA) molecules. However, current standard approaches often use 500 million or …
[HTML][HTML] The biogenesis of the immunopeptidome
A Admon - Seminars in Immunology, 2023 - Elsevier
The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …
I, class II, and non-classical molecules. The peptides are produced by the degradation of …
Differential ion mobility mass spectrometry in immunopeptidomics identifies neoantigens carrying colorectal cancer driver mutations
Y Minegishi, K Kiyotani, K Nemoto, Y Inoue… - Communications …, 2022 - nature.com
Understanding the properties of human leukocyte antigen (HLA) peptides (immunopeptides)
is essential for precision cancer medicine, while the direct identification of immunopeptides …
is essential for precision cancer medicine, while the direct identification of immunopeptides …
Using mass spectrometry to identify neoantigens in autoimmune diseases: the type 1 diabetes example
In autoimmune diseases, recognition of self-antigens presented by major histocompatibility
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …
Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics
M Wacker, J Bauer, L Wessling, M Dubbelaar… - Frontiers in …, 2023 - frontiersin.org
Introduction Mass spectrometry-based immunopeptidomics is the only unbiased method to
identify naturally presented HLA ligands, which is an indispensable prerequisite for …
identify naturally presented HLA ligands, which is an indispensable prerequisite for …