Abstract The last International Classification of Constitutional Disorders of Bone was
published in 1998. Since then rapid advances have been made in identifying the molecular …

Bone mineral density (BMD) is a quantitative trait for which the heritability of the variance is
estimated to be up to 80%, based on epidemiological and twin studies. Further illustration of …

Osteopathia striata with cranial sclerosis (OSCS) is an X‐linked dominant condition marked
by linear striations mainly affecting the metaphyseal region of the long bones and pelvis in …

Osteopathia striata with cranial sclerosis (OS-CS) or Horan-Beighton syndrome is a rare X-
linked dominant inherited bone dysplasia, characterized by longitudinal striations of long …

Osteopathia striata with cranial sclerosis (OSCS) is an X‐linked disease caused by
truncating mutations in WTX. Females exhibit sclerotic striations on the long bones, cranial …

Osteopathia striata with cranial sclerosis (OS‐CS) is a rare syndrome comprising
macrocephaly, minor anomalies, conductive hearing loss, and mild mental retardation. The …

Osteopathia striata with cranial sclerosis (OS–CS) is a rare skeletal dysplasia characterized
by linear striations of the long bones, osteosclerosis of the cranium, and extra‐skeletal …

(CS) is a rare bone dysplasia that presents with variable symptoms mainly due to the
associated CS. Most patients present with the following clinical features related to the cranial …

Osteopathia striata with cranial sclerosis (OSCS) is caused by truncating mutations or
deletions in the X linked gene, WTX, and is characterized by sclerotic striations of the …

Osteopathia striata is a manifestation of several bone dysplasias. In association with cranial
sclerosis, it represents a separate entity that is not limited to the bones, but may also affect …