RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
C Mueller, RH Brown Jr - US Patent 10,280,418, 2019 - Google Patents
7, 498, 316 B2 7, 622, 455 B2 7, 678, 895 B2 7, 691, 995 B2 7, 750, 144 B2 7, 772, 203 B2
7, 892, 793 B2 7, 902, 163 B2 7, 906, 111 B2 8, 008, 271 B2 8, 202, 846 B2 8, 222, 221 B2 …
7, 892, 793 B2 7, 902, 163 B2 7, 906, 111 B2 8, 008, 271 B2 8, 202, 846 B2 8, 222, 221 B2 …
Isolation of novel AAV's and uses thereof
The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful
for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits …
for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits …
Compositions and methods for modulating dysferlin expression
RH Brown Jr, JA Dominov - US Patent 10,689,653, 2020 - Google Patents
7,427,396 B2 7,456,015 B2 7,906,111 B2 8,222,221 B2 8,524,446 B2 8,734,809 B2
9,217,155 B2 9,249,424 B2 2001/0016355 Al 2002/0164783 Al 2002/0192823 A1 …
9,217,155 B2 9,249,424 B2 2001/0016355 Al 2002/0164783 Al 2002/0192823 A1 …
CNS targeting AAV vectors and methods of use thereof
The invention in some aspects relates to recombinant adeno-associated viruses useful for
targeting transgenes to CNS tissue, and compositions comprising the same, and methods of …
targeting transgenes to CNS tissue, and compositions comprising the same, and methods of …
Heterologous targeting peptide grafted AAVS
MS Esteves, SR Choudhury - US Patent 10,370,432, 2019 - Google Patents
The disclosure in some aspects relates to recombinant adeno-associated viruses having
distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer …
distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer …
Recombinant AAVS having useful transcytosis properties
G Gao, L Zhong - US Patent 10,894,949, 2021 - Google Patents
6,485,966 B2 6,498,244 B1 6,544,786 B1 6,953,690 B1 6,962,815 B2 7,022,519 B2
7,198,951 B2 7,235,393 B2 7,427,396 B2 7,456,015 B2 7,906,111 B2 8,222,221 B2 …
7,198,951 B2 7,235,393 B2 7,427,396 B2 7,456,015 B2 7,906,111 B2 8,222,221 B2 …
Recombinant AAV variants and uses thereof
The disclosure in some aspects relates to recombinant adeno-associated viruses having
distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer …
distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer …
AAV treatment of Huntington's disease
C Mueller, N Aronin, EL Pfister - US Patent 10,457,940, 2019 - Google Patents
Aspects of the disclosure relate to compositions and methods useful for treating Huntington's
disease. In some embodiments, the disclosure provides interfering nucleic acids (eg …
disease. In some embodiments, the disclosure provides interfering nucleic acids (eg …