Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Fibroblast growth factor-23 (FGF)-23 is a phosphaturic hormone involved in mineral bone
metabolism that helps control phosphate homeostasis and reduces 1, 25-dihydroxyvitamin …

Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease,
manifested by syncope or sudden death in children or young adults under stress conditions …

Background Cardiac dysfunction and arrhythmia are common and onerous cardiovascular
events in end-stage renal disease (ESRD) patients, especially those on dialysis. Fibroblast …

Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of
mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac …

Background and Purpose Klotho is a membrane‐bound or soluble protein, originally
identified as an age‐suppressing factor and regulator of mineral metabolism. Klotho …

A healthy heart shows intrinsic electrical heterogeneities that play a significant role in
cardiac activation and repolarization. However, cardiac diseases may perturb the baseline …

Background: Acute renal failure (ARF) following renal ischemia-reperfusion (I/R) injury is
considered a relevant risk factor for cardiac damage, but the underlying mechanisms …