The iridium‐catalysed borylation of aromatic C− H bonds has become the preferred method
for the synthesis of aromatic organoboron compounds. The reaction is highly efficient …

Highlights•High quality building blocks can have a big impact on drug discovery.•
Commercial reagents do not satisfy our design criteria or provide sufficient SAR.•Design …

The ability to efficiently synthesize desired compounds can be a limiting factor for chemical
space exploration in drug discovery. This ability is conditioned not only by the existence of …

Herein we disclose a metal-free, N/O-centered radical-promoted Minisci reaction, in which
the coupling of various heteroarenes with simple alkanes proceeds under mild conditions …

The cyclization of heteroatom-containing alkynes with π acidic metal salts is an attractive
method to prepare heterocycles because the starting materials are readily available and the …

Ring systems in pharmaceuticals, agrochemicals, and dyes are ubiquitous chemical motifs.
While the synthesis of common ring systems is well described and novel ring systems can …

Selective introduction of a double bond motif into a multifunctional organic compound is
always a big challenge. The Horner–Wadsworth–Emmons reaction is one of the most …

Abstract Die Ir‐katalysierte Borylierung aromatischer C‐H‐Bindungen ist heute die
bevorzugte Methode zur Synthese aromatischer Organoborverbindungen. Sie ist …

A series of iridium complexes containing phenanthro [4, 5-abc] phenazino [11, 12-d]
imidazol-2-ylidene and acetonaphtho [1, 2-b] quinoxaline [11, 12-d] imidazol-2-ylidene …

New scaffolds for drug discovery, 6‐azaspiro [4.3] alkanes, have been synthesized in two
steps from four‐membered‐ring ketones: cyclobutanone, thienone, N‐Boc‐azetidinone …