Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

Intracellular proteins continuously turn over by degradation and synthesis in all organ
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …

The kidney is the central organ involved in maintaining water and sodium balance. In human
kidneys, nine aquaporins (AQPs), including AQP1–8 and AQP11, have been found and are …

Background Urinary extracellular vesicles (uEVs) are secreted into urine by cells from the
kidneys and urinary tract. Although changes in uEV proteins are used for quantitative …

Ensuring the proper amount of water inside the body is essential for survival. One of the key
factors in the maintenance of body water balance is water reabsorption in the collecting …

In mammals, conservation of body water is critical for survival and is dependent on the
kidneys' ability to minimize water loss in the urine during periods of water deprivation. The …

Renal collecting duct principal cells play a key role in controlling body water balance.
Principal cells express the water channels AQP2, AQP3, and AQP4 that mediate renal water …

Background The NaCl cotransporter NCC in the kidney distal convoluted tubule (DCT)
regulates urinary NaCl excretion and BP. Aldosterone increases NaCl reabsorption via NCC …

The alteration of water balance and related disorders has emerged as being strictly linked to
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …

Aquaporin 2 (AQP2) is a vasopressin (VP)-regulated water channel in the renal collecting
duct. Phosphorylation and ubiquitylation of AQP2 play an essential role in controlling the …