Methamphetamine (METH) is an illicit psychostimulant that is widely abused in the world.
Several lines of evidence suggest that chronic METH abuse leads to neurodegenerative …

The drugs of abuse, methamphetamine and MDMA, produce long‐term decreases in
markers of biogenic amine neurotransmission. These decreases have been traditionally …

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity
back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset …

In animals, sporadic injections of the mitochondrial toxin 1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine (MPTP) selectively damage dopaminergic neurons but do not fully …

Increased autophagic vacuoles (AVs) occur in injured or degenerating neurons, under both
developmental and pathological situations. Although regulation of starvation-induced …

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Amyloidogenic diseases are characterised by the formation of amyloid aggregates inside or
outside the cell. Amyloid-associated human diseases include Alzheimer's disease …

Autophagy is the regulated process by which cytoplasmic organelles and long-lived proteins
are delivered for lysosomal degradation. Increased numbers of autophagosomes and …

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and
powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field …

Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …