Brain tissue responses to neural implants impact signal sensitivity and intervention strategies

TDY Kozai, AS Jaquins-Gerstl… - ACS chemical …, 2015 - ACS Publications
Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors

N Arroyo-Currás, P Dauphin-Ducharme, K Scida… - Analytical …, 2020 - pubs.rsc.org
The ultimate goal of implantable bioanalytical sensors is to enable the continuous and
precise monitoring of clinically and physiologically important targets in the body for …

Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes

IM Taylor, EM Robbins, KA Catt, PA Cody… - Biosensors and …, 2017 - Elsevier
Dopamine (DA) is a monoamine neurotransmitter responsible for regulating a variety of vital
life functions. In vivo detection of DA poses a challenge due to the low concentration and …

Highly Selective Electrochemical Strategy for Monitoring of Cerebral Cu2+ Based on a Carbon Dot-TPEA Hybridized Surface

X Shao, H Gu, Z Wang, X Chai, Y Tian… - Analytical chemistry, 2013 - ACS Publications
Direct determination of cerebral metal ions in small volume biological samples is still the
bottleneck for evaluating the roles that metal ions play in the physiological and pathological …

Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy

JR Eles, AL Vazquez, NR Snyder, C Lagenaur… - Biomaterials, 2017 - Elsevier
Implantable neural electrode technologies for chronic neural recordings can restore
functional control to paralysis and limb loss victims through brain-machine interfaces. These …

Direct in vivo electrochemical detection of resting dopamine using poly (3, 4-ethylenedioxythiophene)/carbon nanotube functionalized microelectrodes

IM Taylor, NA Patel, NC Freedman… - Analytical …, 2019 - ACS Publications
Dopamine (DA) is a monoamine neurotransmitter responsible for the maintenance of a
variety of vital life functions. In vivo DA signaling occurs over multiple time scales, from …

Evaluation of poly (3, 4-ethylenedioxythiophene)/carbon nanotube neural electrode coatings for stimulation in the dorsal root ganglion

CL Kolarcik, K Catt, E Rost, IN Albrecht… - Journal of neural …, 2014 - iopscience.iop.org
Objective. The dorsal root ganglion is an attractive target for implanting neural electrode
arrays that restore sensory function or provide therapy via stimulation. However, penetrating …

Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo

TDY Kozai, AS Jaquins-Gerstl, AL Vazquez… - Biomaterials, 2016 - Elsevier
Intracortical neural probes enable researchers to measure electrical and chemical signals in
the brain. However, penetration injury from probe insertion into living brain tissue leads to an …

In vivo monitoring of dopamine by microdialysis with 1 min temporal resolution using online capillary liquid chromatography with electrochemical detection

H Gu, EL Varner, SR Groskreutz, AC Michael… - Analytical …, 2015 - ACS Publications
Microdialysis is often applied to understanding brain function. Because neurotransmission
involves rapid events, increasing the temporal resolution of in vivo measurements is …

A two-channel ratiometric electrochemical biosensor for in vivo monitoring of copper ions in a rat brain using gold truncated octahedral microcages.

X Chai, X Zhou, A Zhu, L Zhang, Y Qin… - Angewandte …, 2013 - search.ebscohost.com
To develop in vivo monitoring strategies of physiologically important species involved in
brain chemistry is a challenging work for progress in understanding the roles that …