Rosmarinic acid exhibits anticancer effects via MARK4 inhibition
Microtubule affinity regulating kinase (MARK4) is a potential drug target for different types of
cancer as it controls the early step of cell division. In this study, we have screened a series of …
cancer as it controls the early step of cell division. In this study, we have screened a series of …
Binding sites of anticancer drugs on human serum albumin (HSA): a review
P Molaei, H Mahaki, H Manoochehri… - Protein and peptide …, 2022 - ingentaconnect.com
Background: To recognize the action of pharmacologically approved anticancer drugs in
biological systems, information regarding its pharmacokinetics, such as its transport within …
biological systems, information regarding its pharmacokinetics, such as its transport within …
MARK4 inhibited by AChE inhibitors, donepezil and Rivastigmine tartrate: insights into Alzheimer's disease therapy
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer's disease (AD)
development as its overexpression is directly linked to increased tau phosphorylation …
development as its overexpression is directly linked to increased tau phosphorylation …
Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6
Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus,
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …
Comprehensive insight into the molecular interaction of rutin with human transferrin: Implication of natural compounds in neurodegenerative diseases
Neurodegeneration, a process of irreversible neuronal damage, is characterized by a
damaged neuronal structure and function. The interplay between various proteins maintains …
damaged neuronal structure and function. The interplay between various proteins maintains …
Structure‐based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases
MAP/microtubule affinity‐regulating kinase 4 (MARK4) is a member of serine/threonine
kinase family and considered an attractive drug target for many diseases. Screening of …
kinase family and considered an attractive drug target for many diseases. Screening of …
Interaction of an abiraterone with calf thymus DNA: Investigation with spectroscopic technique and modelling studies
Binding of toxic ligands to DNA could result in undesirable biological processes, such as
carcinogenesis or mutagenesis. Binding mode of Abiraterone (ABR), a steroid drug and calf …
carcinogenesis or mutagenesis. Binding mode of Abiraterone (ABR), a steroid drug and calf …
Inhibiting CDK6 activity by quercetin is an attractive strategy for cancer therapy
Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in
the progression of different types of cancers. We performed in silico and in vitro screening of …
the progression of different types of cancers. We performed in silico and in vitro screening of …
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
Understanding the binding between Rosmarinic acid and serum albumin: In vitro and in silico insight
Rosmarinic acid (RA) is a natural product that is increasingly being used in food industries
and cosmetic industries. Drug pharmacokinetics is affected upon binding with protein, thus …
and cosmetic industries. Drug pharmacokinetics is affected upon binding with protein, thus …