[HTML][HTML] Preservation of biomaterials and cells by freeze-drying: Change of paradigm

A Merivaara, J Zini, E Koivunotko, S Valkonen… - Journal of Controlled …, 2021 - Elsevier
Freeze-drying is the most widespread method to preserve protein drugs and vaccines in a
dry form facilitating their storage and transportation without the laborious and expensive cold …

Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery

P Fonte, S Reis, B Sarmento - Journal of controlled release, 2016 - Elsevier
Lyophilization has been used to improve the long-term stability of polymeric nanoparticles
for drug delivery applications, avoiding their instability in suspension. However, this …

Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs

QK Anjani, AD Permana, Á Cárcamo-Martínez… - European Journal of …, 2021 - Elsevier
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and
intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal …

Parenteral protein formulations: an overview of approved products within the European Union

V Gervasi, RD Agnol, S Cullen, T McCoy… - European Journal of …, 2018 - Elsevier
The study presented is a comprehensive overview of commercial parenteral protein
formulations, approved by the European Medicines Agency (EMA), 1995–2018. The …

Excipients in freeze-dried biopharmaceuticals: Contributions toward formulation stability and lyophilisation cycle optimisation

M Bjelošević, AZ Pobirk, O Planinšek… - International journal of …, 2020 - Elsevier
Biopharmaceuticals are one of the fastest growing areas within the pharmaceutical industry.
As protein drugs require parenteral administration, they are commonly formulated as …

Lyophilized liposome-based parenteral drug development: Reviewing complex product design strategies and current regulatory environments

Y Wang, DW Grainger - Advanced drug delivery reviews, 2019 - Elsevier
Given the successful entry of several liposomal drug products into market, and some with
decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to …

Excipients in parenteral formulations: selection considerations and effective utilization with small molecules and biologics

BM Rayaprolu, JJ Strawser… - Drug development and …, 2018 - Taylor & Francis
Excipients form a major component of pharmaceutical formulations and are classified as any
ingredient other than the active ingredient which is included within the product formulation to …

A lyophilized colorimetric RT-LAMP test kit for rapid, low-cost, at-home molecular testing of SARS-CoV-2 and other pathogens

X Song, FJ Coulter, M Yang, JL Smith, FG Tafesse… - Scientific Reports, 2022 - nature.com
Access to fast and reliable nucleic acid testing continues to play a key role in controlling the
COVID-19 pandemic, especially in the context of increased vaccine break-through risks due …

Freeze-drying process for the fabrication of collagen-based sponges as medical devices in biomedical engineering

C Katrilaka, N Karipidou, N Petrou, C Manglaris… - Materials, 2023 - mdpi.com
This paper presents a systematic review of a key sector of the much promising and rapidly
evolving field of biomedical engineering, specifically on the fabrication of three-dimensional …

Lyophilization of small-molecule injectables: an industry perspective on formulation development, process optimization, scale-up challenges, and drug product quality …

A Butreddy, N Dudhipala, KY Janga, RP Gaddam - Aaps Pharmscitech, 2020 - Springer
Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is
unstable as a ready-to-use formulation. Some formulations may require the addition of drug …