Recent trends in praziquantel nanoformulations for helminthiasis treatment

AC Mengarda, B Iles, JP F. Longo… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Infections caused by parasitic flatworms impose a considerable worldwide
health burden. Recently, World Health Organization launched its roadmap for neglected …

Drug repurposing: considerations to surpass while re-directing old compounds for new treatments

D Juárez-López, A Schcolnik-Cabrera - Archives of Medical Research, 2021 - Elsevier
Drug repurposing has increased in recent years as an attractive option for treating a number
of diseases. Compared to those brought forward via traditional chemical development, drugs …

[HTML][HTML] Therapeutic efficacy of carvacrol-loaded nanoemulsion in a mouse model of schistosomiasis

ES Xavier, RL de Souza, VC Rodrigues… - Frontiers in …, 2022 - frontiersin.org
Since praziquantel is the only drug available to treat schistosomiasis, a neglected parasitic
disease that affects more than 240 million people worldwide, there is an urgent demand for …

Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic …

MP Silva, TM Silva, AC Mengarda, MC Salvadori… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Propolis has been used in folk medicine for thousands of
years and, in the past few decades, it has attracted renewed interest. Although propolis has …

[HTML][HTML] Susceptibility of Angiostrongylus cantonensis larvae to anthelmintic drugs

DB Roquini, GL Silva, LLG Ferreira… - Frontiers in …, 2022 - frontiersin.org
Human helminthiasis affects approximately one in five people in the world and
disproportionally affects the poorest and most deprived communities. Human …

Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis

AC Mengarda, PS Mendonca, CS Morais, RM Cogo… - Acta tropica, 2020 - Elsevier
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …

Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni …

AC Mengarda, MP Silva, ME Cirino… - Phytotherapy …, 2021 - Wiley Online Library
Schistosomiasis is a widespread human parasitic disease currently affecting over 200
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …

[HTML][HTML] Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni

JR Brito, P Wilairatana, DB Roquini, BC Parra… - Scientific Reports, 2022 - nature.com
Schistosomiasis, a parasitic disease caused by the blood fluke of the genus Schistosoma,
affects over 230 million people, especially in developing countries. Despite the significant …

15β-Senecioyl-oxy-ent-kaur-16-en-19-oic Acid, a Diterpene Isolated from Baccharis lateralis, as Promising Oral Compound for the Treatment of Schistosomiasis

DP Sessa, AC Mengarda, PE Simplicio… - Journal of Natural …, 2020 - ACS Publications
Praziquantel is the only available drug to treat schistosomiasis, and therefore, urgent studies
must be performed to identify new anthelmintic agents. This study reports the anthelmintic …

[HTML][HTML] Pyrazoline derivatives as promising novel antischistosomal agents

CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that
currently infects more than 240 million people globally. Due to increasing concerns about …