Pioneer of prostate cancer: past, present and the future of FOXA1
Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American
men. While androgen deprivation has remained as the cornerstone of prostate cancer …
men. While androgen deprivation has remained as the cornerstone of prostate cancer …
[HTML][HTML] Target 2035: probing the human proteome
AJ Carter, O Kraemer, M Zwick, A Mueller-Fahrnow… - Drug Discovery …, 2019 - Elsevier
Highlights•Natural tendency for researchers to focus on a small fraction of the human
proteome.•Pharmacological modulators are one of the best ways of interrogating the …
proteome.•Pharmacological modulators are one of the best ways of interrogating the …
Colorectal cancer organoid–stroma biobank allows subtype-specific assessment of individualized therapy responses
In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy
efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical …
efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical …
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …
PRMT5 inhibition disrupts splicing and stemness in glioblastoma
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 …
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 …
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1
Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei
KM MacDonald, S Nicholson-Puthenveedu… - Nature …, 2023 - nature.com
Micronuclei (MN) are cytosolic bodies that sequester acentric fragments or mis-segregated
chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows …
chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows …
[HTML][HTML] A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
D Dilworth, RP Hanley, R Ferreira de Freitas… - Nature chemical …, 2022 - nature.com
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …
Probing the SAM binding site of SARS-CoV-2 Nsp14 in vitro using SAM competitive inhibitors guides developing selective bisubstrate inhibitors
The COVID-19 pandemic has clearly brought the healthcare systems worldwide to a
breaking point, along with devastating socioeconomic consequences. The SARS-CoV-2 …
breaking point, along with devastating socioeconomic consequences. The SARS-CoV-2 …
Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase
An under-explored target for SARS-CoV-2 is the S-adenosyl methionine (SAM)-dependent
methyltransferase Nsp14, which methylates the N7-guanosine of viral RNA at the 5′-end …
methyltransferase Nsp14, which methylates the N7-guanosine of viral RNA at the 5′-end …