Simple Summary This review summarizes the current knowledge on mesothelin's function,
its role in cancer, and opportunities for immunotherapeutic targeting of mesothelin …

Cancer is one of the prominent causes of death worldwide. Despite the existence of various
modalities for cancer treatment, many types of cancer remain uncured or develop resistance …

Epigenetics is a relatively recent field of molecular biology that has arisen over the past 25
years. Cancer is now understood to be a disease of widespread epigenetic dysregulation …

Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos
exposure. There are few effective treatment options for mesothelioma, and patients have a …

In an effort to identify acute myeloid leukemia (AML)-restricted targets for therapeutic
development in AML, we analyzed the transcriptomes of 2051 children and young adults …

Immunotoxins are a class of targeted cancer therapeutics in which a toxin such as
Pseudomonas exotoxin A (PE) is linked to an antibody or cytokine to direct the toxin to a …

Purpose: We previously identified mesothelin (MSLN) as highly expressed in a significant
fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis …

Mesothelin is a tumor differentiation antigen, which is highly expressed in several solid
neoplasms, including pancreatic cancer. Its selective expression on malignant cells and on …

Purpose Treatment of cancer using standard chemotherapy still offers a poor prognosis
combined with severe side effects. Novel antibody-based therapies have been shown to …

HA22 (Moxetumomab pasudotox) is a recombinant immunotoxin (RIT), composed of an anti-
CD22 Fv fused to a truncated portion of Pseudomonas exotoxin A. HA22 is in clinical trials to …