Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …

The functions of intrinsically disordered proteins (IDPs) are governed by relationships
between information encoded in their amino acid sequences and the ensembles of …

Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …

A variety of membraneless organelles, often termed “biological condensates”, play an
important role in the regulation of cellular processes such as gene transcription, translation …

RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …

Alternative inclusion of exons increases the functional diversity of proteins. Among
alternatively spliced exons, tissue-specific exons play a critical role in maintaining tissue …

RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …

Linker histones bind to the nucleosome and regulate the structure of chromatin and gene
expression. Despite more than three decades of effort, the structural basis of nucleosome …