Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity …

The dissemination of cancer cells from the primary tumor to a distant site, known as
metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex …

Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed
by invasive cancer cells. We have studied the molecular mechanisms of invadopodium …

Metastatic tumor cells that actively migrate and invade surrounding tissues rely on
invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membrane …

The spread of cancer cells to distant sites in the body is the major cause of cancer patient
death. Growing evidence connects specialized subcellular structures, invadopodia, to …

Oncofetal RNA‐binding IMPs have been implicated in mRNA localization, nuclear export,
turnover and translational control. To depict the cellular actions of IMPs, we performed a loss …

Advances in our understanding of the mechanisms of lamellipodia and filopodia assembly
have led to a better concept of how cells move, including how the actin cytoskeleton might …

The causes of metastasis remain elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow-derived cells …