The incidence of malignant melanoma has continued to rise during the past decades.
However, in the last few years, treatment protocols have significantly been improved thanks …

Autophagy is a homeostatic mechanism through which intracellular damaged organelles
and proteins are degraded and recycled in response to increased metabolic demands or …

Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for
atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an …

ROS and oxidative stress may promote autophagy; on the other hand, autophagy may help
reduce oxidative damages. According to the known interplay of ROS, autophagy, and …

Malignant melanoma is the leading cause of death from skin cancer. Drug toxicity and
resistance represent a serious challange for melanoma treatments. Evidence demonstrates …

Despite the depth of knowledge concerning the pathogenesis of melanoma, the most
aggressive type of skin cancer, the prognosis and survival of patients still remain a …

Melanoma is one of the most aggressive types of skin cancer with rapidly increasing
incidence rate. The disease is largely considered incurable and the patients diagnosed with …

Endoplasmic reticulum (ER) stress-induced apoptosis plays an important role in a range of
neurological disorders, such as neurodegenerative diseases, spinal cord injury, and …

BRAF is a member of the RAF family of serine/threonine-specific protein kinases. Oncogenic
BRAF, in particular, BRAF V600E, can disturb the normal protein folding machinery in the …

The pancreatic cancer is the fourth leading cause of cancer-related death and characterized
by one of the lowest five-year survival rate. The current therapeutic options are …