Chronic antigenic stimulation leads to gradual accumulation of late‐differentiated, antigen‐
specific, oligoclonal T cells, particularly within the CD8+ T‐cell compartment. They are …

The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally
differentiated 'senescent'cells with reduced proliferative capacity and altered functional …

Historically, human NK cells have been identified as CD3− CD56+ CD16±lymphocytes.
More recently it has been established that CD57 expression defines functionally discrete …

In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis causes the
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, which is associated with
profound alterations and defects in the immune system and a prevalent dependency on the …

Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to
profound T-cell defects. T-cell functions also depend on co-signaling receptors, inhibitory or …

Abstract Cytotoxic CD4+ CD28− T cells form a rare subset in human peripheral blood. The
presence of CD4+ CD28− cells has been associated with chronic viral infections, but how …

The finding that chronic lymphocytic leukemia (CLL) consists of 2 clinical subsets,
distinguished by the incidence of somatic mutations in the immunoglobulin (Ig) variable …

CD57+ expression in T lymphocytes has been recognized for decades as a marker of in vitro
replicative senescence. In recent years, accumulating evidences have pointed on the utility …

PURPOSE: To review the recent major advances in the molecular and cell biology of B-cell
chronic lymphocytic leukemia (B-CLL). METHODS: We analyzed the nature of malignant B …