T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

The importance of immunoproteasomes to antigen presentation has been unclear because
animals totally lacking immunoproteasomes had not been available. Having now developed …

A remarkable characteristic of the human major histocompatibility complex (MHC) is its
extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC …

ERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1
has unique substrate preferences, trimming long peptides but sparing shorter ones. To …

Major histocompatibility complex (MHC) class I molecules present peptides on the cell
surface to CD8+ T cells, which is critical for the killing of virus-infected or transformed cells …

Macroautophagy serves cellular housekeeping and metabolic functions through delivery of
cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the …

We encounter pathogens on a daily basis and our immune system has evolved to mount an
immune response following an infection. An interesting phenomenon that has evolved in …

The processing of MHC class I antigenic precursor peptides by the endoplasmic reticulum
aminopeptidase 1 (ERAP1) and ERAP2 is an important event in the cell biology of antigen …

MHC class I molecules present a variable but limited repertoire of antigenic peptides for T-
cell recognition. Understanding how peptide selection is achieved requires mechanistic …