Inflammation in Development and Aging: Insights from the Zebrafish Model

M Mastrogiovanni, FJ Martínez-Navarro… - International Journal of …, 2024 - mdpi.com
Zebrafish are an emergent animal model to study human diseases due to their significant
genetic similarity to humans, swift development, and genetic manipulability. Their utility …

p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation

CA Campbell, R Calderon, G Pavani, X Cheng… - Nature …, 2024 - nature.com
Most gene functions have been discovered through phenotypic observations under loss of
function experiments that lack temporal control. However, cell signaling relies on limited …

Blood and guts: how the intestinal microbiome shapes hematopoiesis and treatment of hematologic disease

J Fernandez Sanchez, AA Maknojia, KY King - Blood, 2024 - ashpublications.org
Over the past 10 years, there has been a marked increase in recognition of the interplay
between the intestinal microbiome and the hematopoietic system. Despite their apparent …

Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis

MB Wilken, G Fonar, R Qiu, L Bennett, J Tober… - Stem Cell Reports, 2024 - cell.com
Tropomyosins coat actin filaments to impact actin-related signaling and cell morphogenesis.
Genome-wide association studies have linked Tropomyosin 1 (TPM1) with human blood trait …

[HTML][HTML] Integrated local and systemic communication factors regulate nascent hematopoietic progenitor escape during developmental hematopoiesis

C Shalaby, J Garifallou, CS Thom - International Journal of Molecular …, 2024 - mdpi.com
Mammalian blood cells originate from specialized 'hemogenic'endothelial (HE) cells in
major arteries. During the endothelial-to-hematopoietic transition (EHT), nascent …

Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis

P Kang, P Liu, J Kim, A Kumar, M Bolton, W Murzyna… - …, 2024 - pmc.ncbi.nlm.nih.gov
The prothoracicotropic hormone (PTTH) is a well-known neuropeptide that regulates insect
metamorphosis (the juvenile-to-adult transition) by inducing the biosynthesis of steroid …

The role of nfkb1 in hemogenic endothelial cell production

G Dubansky - 2023 - search.proquest.com
Blood related disorders like acute myelogenous leukemia often rely on allogeneic
hematopoietic stem cell transplantations as a form of therapy. However, graft-versus-host …