Extracorporeal circulation (ECC) systems, including cardiopulmonary bypass, and
extracorporeal membrane oxygenation have been an irreplaceable part of the …

Abstract Introduction Mock circulatory loops (MCLs) are mechanical representations of the
cardiovascular system largely used to test the hemodynamic performance of cardiovascular …

In this work, a novel mock circulatory loop (MCL) is presented that is capable of simulating
both healthy cardiac function and Heart Failure with preserved Ejection Fraction (HFpEF) …

Ex situ heart perfusion (ESHP) has emerged as an important strategy to preserve donation
after brain death (DBD) and donation after circulatory death (DCD) donor hearts. Clinically …

Cardiovascular diseases are the leading cause of morbidity and mortality and a huge
economic burden on the healthcare system globally. Both pharmacological and device …

Heart transplantation is associated with major hurdles, including the limited number of
available organs for transplantation, the risk of rejection due to genetic discrepancies, and …

The aim was to optimize the perfusate composition by including a hemofiltrator to the
PhysioHeartplatform for ex situ heart perfusion of porcine slaughterhouse hearts. Fourteen …

Background A translational ex vivo perfusion-based mandibular pig model was developed
as an alternative to animal experiments, for initial assessment of biomaterials in dental and …

Preclinical testing of medical devices is an essential step in the product life cycle, whereas
testing of cardiovascular implants requires specialised testbeds or numerical simulations …

For recent decades, cardiac diseases have been the leading cause of death and morbidity
worldwide. Despite significant achievements in their management, profound understanding …